Antidepressants can weaken bones!

Antidepressants can be harmful to your bones. People using selective serotonin reuptake inhibitors (SSRIs) are found to have a higher risk of bone fracture, but it is not clear that this is the cause of the drugs or depression.

Patricia Ducy of the University of Colombia, New York, says it is a bit confusing and surprising, but she and her team are working with mice to get "fluoxetine," an active ingredient in Prozac (antidepressant) for 6 weeks, Mass loss.



The team measures the bones in a two-step process: blood and gene activity. In the first three weeks, fluoxetine helps strengthen bones by weakening osteoclast cells, which are bone destroying cells, which usually reduce bone tissue. At the end of 6 weeks, however, the high level of serotonin activated by this drug reduces the power of the "hypothalamus", the region supporting the brain's bone development.

Ducy: "Even though we have seen bone strength in the first three weeks, it has not been very long with the adverse effects of this drug, and it has been spotted missing suddenly."

Two-Stage Process

 Ducy says that people with these two-step molds are also seen. The risk of breakage of the bones of fluoxetine sites in a short-term process is minimal, but the risk of bone erosion and fracture increases in the field for a year or more.

René Rizzoli of the University Hospital of Geneva, Switzerland, notes that this study is a very good work in showing the mechanism of selective serotonin reuptake inhibitors (SSGI) affecting the bones.

It was difficult to say that depression, caused by the change of lifestyles, such as cigarettes, drinking more and drinking bad eating habits, may cause bone fractures. In the meantime, other Selective Serotonin Receptor Inhibitors (SSGI) drugs may not show the same effect. For example; Ducy's team also finds that citalopram, a selective serotonin reuptake inhibitor (SSGI), does not have any positive or negative effects on bones.